||Chronic exposure to metals such as nickel, gold, palladium, mercury, and titanium in jewelry, dental implants and restorations, cosmetics, and joint prostheses can sensitize genetically predisposed individuals and induce a so-called type IV hypersensitivity reaction.
While such a reaction typically manifests itself as contact dermatitis, chronic exposure may also induce systemic effects including headache, migraine, neuralgia, depression, insomnia, arthralgia, paresthesia, fatigue, and immune dysfunction. Removal or avoidance of the allergenic metal can significantly improve clinical symptoms.
With the standardized and validated in vitro lymphocyte transformation test (LTT), metal sensitivity can be diagnosed more reliably and without the inadvertent in vivo sensitization associated with skin testing.
- Multiple sclerosis (MS) and other autoimmune disorders.
- Chronic fatigue syndrome.
- Multiple chemical sensitivity (MCS).
- Oral lichen planus.
- Burning mouth syndrome.
- Contact dermatitis/eczema.
- Unexplained pain, fatigue, insomnia, depression.